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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3A
All Species:
31.82
Human Site:
S393
Identified Species:
50
UniProt:
P49840
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49840
NP_063937.2
483
50981
S393
Y
T
P
S
S
R
L
S
P
L
E
A
C
A
H
Chimpanzee
Pan troglodytes
XP_530044
483
51007
S393
Y
T
P
S
S
R
L
S
P
L
E
A
C
A
H
Rhesus Macaque
Macaca mulatta
XP_001104964
483
50993
S393
Y
T
P
S
S
R
L
S
P
L
E
A
C
A
H
Dog
Lupus familis
XP_852706
441
48143
S351
Y
T
P
S
S
R
L
S
P
L
E
A
C
A
H
Cat
Felis silvestris
Mouse
Mus musculus
Q2NL51
490
51642
S394
Y
T
P
S
S
R
L
S
P
L
E
A
C
A
H
Rat
Rattus norvegicus
P18265
483
51008
S393
Y
T
P
S
S
R
L
S
P
L
E
A
C
A
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
P344
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
Frog
Xenopus laevis
NP_001083752
420
46885
T330
Y
T
P
T
S
R
L
T
P
L
D
A
C
A
H
Zebra Danio
Brachydanio rerio
NP_001038386
462
50821
R373
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
T881
Y
T
P
S
A
R
I
T
P
L
K
A
C
A
H
Honey Bee
Apis mellifera
XP_392504
434
48445
A345
I
T
P
L
E
A
C
A
H
P
F
F
D
E
L
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
F273
P
N
Y
K
E
F
K
F
P
Q
I
K
A
H
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
P205
V
N
Q
K
P
L
F
P
G
D
S
E
I
D
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
W319
P
Q
I
K
A
H
P
W
H
K
I
F
H
K
R
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
P281
H
K
F
P
Q
I
K
P
I
P
L
S
R
V
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.7
85.5
N.A.
93.8
97
N.A.
N.A.
67.9
67.4
71.8
N.A.
33.4
64.1
55.2
N.A.
Protein Similarity:
100
99.7
99.7
86.3
N.A.
95.5
97.7
N.A.
N.A.
74.9
74.5
77.6
N.A.
38
75.1
63.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
0
80
13.3
N.A.
73.3
13.3
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
6.6
100
20
N.A.
100
20
6.6
N.A.
Percent
Protein Identity:
N.A.
24.4
N.A.
52.8
40.7
N.A.
Protein Similarity:
N.A.
38.1
N.A.
63.7
55.4
N.A.
P-Site Identity:
N.A.
0
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
0
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
14
14
7
0
7
0
0
7
54
14
54
0
% A
% Cys:
0
0
0
0
0
7
7
0
0
0
0
7
54
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
7
7
0
7
7
0
% D
% Glu:
7
0
0
0
14
0
0
0
0
7
47
7
0
7
7
% E
% Phe:
0
0
7
0
0
7
7
7
0
0
7
14
0
0
7
% F
% Gly:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% G
% His:
7
0
0
0
0
7
0
0
14
0
0
0
7
14
54
% H
% Ile:
7
0
14
0
0
7
7
0
7
0
14
0
7
0
0
% I
% Lys:
0
7
0
20
0
0
14
0
0
7
7
7
0
7
0
% K
% Leu:
0
0
0
7
7
14
47
0
14
60
7
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
14
7
60
7
7
0
7
20
60
14
0
0
0
7
7
% P
% Gln:
0
7
7
0
7
0
0
0
0
7
0
0
0
0
0
% Q
% Arg:
0
0
0
0
7
54
0
7
0
0
0
0
7
0
7
% R
% Ser:
0
0
0
47
47
0
7
40
0
0
7
7
0
0
7
% S
% Thr:
7
60
7
7
0
0
7
14
0
0
0
0
7
0
0
% T
% Val:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
54
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _